Pesquisa | SciELO

Resumen: A veces existen límites claros y naturales del campo de acción de una ciencia, y en otros casos son simples límites de conveniencia. La Ciencia de la Información Geográfica (CIG) es una ciencia transversal, que tiene contactos con todas las geociencias y con diversas ciencias formales como las Matemáticas, la Lógica y la Informática. Una primera aproximación razonable a los límites de una ciencia sería a través de su definición. Sin embargo, las definiciones existentes de CIG a menudo son tan amplias que han sido criticadas con razón por practicar el gerrymandering, en particular con el resto de las geociencias. Para evitar el gerrymandering se propone una definición operacional que ubica a la CIG entre las ciencias que manejan Datos y no Información. Esto resuelve el problema del gerrymandering sin implicar realmente un recorte significativo de lo que normalmente se considera dentro de CIG. Una consecuencia no prevista es que esto permitirá caracterizar a la CIG como Ciencia Formal.

Abstract: Sometimes there are clear and natural limits to the scope of action of a science, and in other cases they are simply convenient ones. Geographic Information Science (GISc) is a transversal science, with contacts with all geosciences but also with various formal sciences such as Mathematics, Logic and Computer Science. A first approach to specifying the limits of a science is through its definition. Definitions of GISc are often so expansive that they have been rightly criticized for practicing gerrymandering, in particular with the rest of the geosciences. To avoid this, an operational definition is proposed that places GISc among the sciences that handle Data and not Information. This solves the gerrymandering problem without really implying a significant cut of what is usually considered within GISc. As an unforeseen consequence, this delimitation will allow it to be characterized as Formal Science, leaving it as the only geoscience with this characteristic.

https://doi.org/10.35424/rcarto.i1070.4669

Compared efficacy of rituximab, abatacept, and tocilizumab in patients with rheumatoid arthritis refractory to methotrexate or TNF inhibitors agents: a systematic review and network meta-analysis
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Pugliesi, Alisson

; Oliveira, Amanda Borges de

; Oliveira, Ana Beatrice

; Xavier, Ricardo

; Mota, Licia Maria Henrique da

; Bertolo, Manoel Barros

; Gonzalez-Gay, Miguel Angel

; Citera, Gustavo

; Carvalho, Luiz Sergio Fernandes de

Advances in Rheumatology

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2023, Volume 63 elocation 30

Resumo: En | Texto: En | PDF: En

Abstract Background Our aim was to compare the efficacy of rituximab, tocilizumab, and abatacept in individuals with rheumatoid arthritis (RA) refractory to treatments with MTX or TNFi agents. Methods We searched 6 databases until January 2023 for phase 2–4 RCTs evaluating patients with RA refractory to MTX or TNFi therapy treated with rituximab, abatacept, and tocilizumab (intervention arm) compared to controls. Study data were independently assessed by two investigators. The primary outcome was considered as achieving ACR70 response. Results The meta-analysis included 19 RCTs, with 7,835 patients and a mean study duration of 1.2 years. Hazard ratios for achieving an ACR70 response at six months were not different among the bDMARDs, however, we found high heterogeneity. Three factors showing a critical imbalance among the bDMARD classes were identified: baseline HAQ score, study duration, and frequency of TNFi treatment in control arm. Multivariate meta-regression adjusted to these three factors were conducted for the relative risk (RR) for ACR70. Thus, heterogeneity was attenuated (I2 = 24%) and the explanatory power of the model increased (R2 = 85%). In this model, rituximab did not modify the chance of achieving an ACR70 response compared to abatacept (RR = 1.773, 95%CI 0.113–10.21, p = 0.765). In contrast, abatacept was associated with RR = 2.217 (95%CI 1.554–3.161, p < 0.001) for ACR70 compared to tocilizumab. Conclusion We found high heterogeneity among studies comparing rituximab, abatacept, and tocilizumab. On multivariate metaregressions, if the conditions of the RCTs were similar, we estimate that abatacept could increase the chance of reaching an ACR70 response by 2.2-fold compared to tocilizumab. Key messages Abatacept could increase the chance of reaching an ACR70 response by 2.2-fold compared to tocilizumab.

https://doi.org/10.1186/s42358-023-00298-z

Adverse effects associated with peribulbar injection of triamcinolone for the treatment of thyroid eye disease: a retrospective case series
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Barlatay, Joaquin Miguel Gonzalez

; Boza, Carla Pagano

; Basso, Tomaz Ortiz

; Benavente, Mercedes

; Hernández-Gauna, Guillermo Vicente

; Premoli, Eduardo Jorge

Arquivos Brasileiros de Oftalmologia

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2023, Volume 86 Nº 5 elocation e20230063

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Purpose: Peribulbar injection of triamcinolone is an alternative treatment for thyroid eye disease; however the safety profile of this therapeutic option remains controversial. The aim of this study was to describe the occurrence of local and systemic adverse effects after peribulbar injection of triamcinolone in patients with thyroid eye disease. Methods: This was a retrospective case series. Medical records of patients with thyroid eye disease treated with peribulbar injections of triamcinolone at a single academic institution between 2007 and 2019 were analyzed. Local and systemic complications were documented. Results: A total of 123 patients were treated. Only 11 patients (8.9%) developed local complications. The most frequent complication was the presence of superficial eyelid ecchymosis (nine patients; 7.3%). Notably, systemic complications (hyperglycemic and suprarenal inhibition after stop treatment) occurred in two patients (1.6%). All complications were transient, and the patients did not have any long-term sequelae. Conclusions: Peribulbar injection of triamcinolone for the treatment of thyroid eye disease is linked to a very low rate of local or systemic complications. Prospective studies are warranted to delve into this topic.

RESUMO Objetivo: A injeção peribulbar de triancinolona é um tratamento alternativo para doenças oculares da tireoide; no entanto, a segurança desse procedimento continua controversa. O objetivo deste artigo é descrever os efeitos adversos locais e sistêmicos de injeções peribulbares de triancinolona em pacientes com doença ocular da tireoide. Métodos: Estudo retrospectivo de uma série de casos. Foram analisados os prontuários médicos dos pacientes com doença ocular da tireoide tratados com injeções de triancinolona peribulbar em uma única instituição acadêmica entre 2007 e 2019. Foram documentadas as complicações locais e sistêmicas. Resultados: Um total de 123 pacientes foram tratados. Apenas 11 (8,9%) pacientes apresentaram complicações locais, sendo a mais frequente a presença de equimoses palpebrais superficiais (7,3%), enquanto 2 (1,6%) pacientes apresentaram complicações sistêmicas (hiperglicemia e inibição da suprarrenal após a interrupção do tratamento). Todas estas complicações foram transitórias e nenhum paciente apresentou sequelas de longo prazo. Conclusões: As injeções peribulbares de triancinolona nas doenças oculares da tireoide têm uma taxa muito baixa de complicações, tanto locais quanto sistêmicas. São necessários estudos prospectivos para aprofundar este tópico.

https://doi.org/10.5935/0004-2749.20230063

Detection of People Positive to COVID-19 through ATR-FTIR Spectra Analysis of Saliva using Machine Learning
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Vazquez-Zapien, Gustavo Jesús

; Mata-Miranda, Monica Maribel

; Martinez-Cuazitl, Adriana

; Guerrero-Ruiz, Melissa

; Garibay-Gonzalez, Francisco

; Sanchez-Brito, Miguel

Revista mexicana de ingeniería biomédica

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Dez 2022, Volume 43 Nº 3 elocation 1304

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La COVID-19 es una enfermedad infecciosa ocasionada por el virus SARS-CoV-2. La propagación de este virus se produce principalmente a través de gotitas liberadas por la nariz o la boca de una persona infectada. Aunque se han desarrollado vacunas que permiten reducir efectivamente los efectos que esta infección viral provoca, el método más eficaz para contener la propagación del virus son las numerosas pruebas para detectar y aislar los posibles portadores. Sin embargo, el tiempo de respuesta, combinado con el costo de las pruebas reales, hace que esta opción sea poco práctica. Aquí, comparamos algunas metodologías de machine learning para proponer una estrategia confiable para detectar personas positivas a COVID-19 analizando espectros de saliva obtenidos por espectroscopia infrarroja transformada de Fourier (FTIR). Tras analizar 1275 espectros, con 7 estrategias comúnmente empleadas en el área de machine learning, concluimos que un modelo de regresión lineal multivariante (MLMR) resulta ser la mejor opción para identificar posibles infectados. De acuerdo con nuestros resultados, el desplazamiento observado en la región de la amida I del espectro, resulta fundamental y confiable para establecer una frontera a partir del cambio de pendiente que este provoca. Al ser más ágil y económica que la reacción en cadena de la polimerasa con transcriptasa inversa (RT-PCR), podría aplicarse confiablemente como estrategia preliminar a RT-PCR.

ABSTRACT COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. This virus's spread is mainly through droplets released from the nose or mouth of an infected person. Although vaccines have been developed that effectively reduce the effects that this viral infection causes, the most effective method to contain the virus’s spread is numerous tests to detect and isolate possible carriers. However, the response time, combined with the cost of actual tests, makes this option impractical. Herein, we compare some machine learning methodologies to propose a reliable strategy to detect people positive to COVID-19, analyzing saliva spectra obtained by Fourier transform infrared (FTIR) spectroscopy. After analyzing 1275 spectra, with 7 strategies commonly used in machine learning, we concluded that a multivariate linear regression model (MLMR) turns out to be the best option to identify possible infected persons. According to our results, the displacement observed in the region of the amide I of the spectrum, is fundamental and reliable to establish a border from the change in slope that causes this displacement that allows us to characterize the carriers of the virus. Being more agile and cheaper than reverse transcriptase polymerase chain reaction (RT-PCR), it could be reliably applied as a preliminary strategy to RT-PCR.

https://doi.org/10.17488/rmib.43.3.5

Acute kidney injury outcomes in covid-19 patients: systematic review and meta-analysis
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Silva, Beatriz Moreira

; Assis, Letícia Cristina Silva De

; Batista Júnior, Maurício De Castro

; Gonzalez, Naara Affonso Philipps

; Anjos, Samuel Benni Dos

; Goes, Miguel Angelo

Brazilian Journal of Nephrology

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Dez 2022, Volume 44 Nº 4 Páginas 543 - 556

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background: Acute kidney injury (AKI) is a frequent complication of coronavirus-19 disease (COVID-19). Therefore, we decided to perform a systematic review and meta-analysis with data from the literature to relate the development of COVID-19 associated-AKI with comorbidities, medications, and the impact of mechanical ventilation. Methods: We performed a systematic review using the Newcastle-Ottawa scale and a meta-analysis using the R program. Relevant studies were searched in the PubMed, Medline, and SciELO electronic databases. Search filters were used to include reports after 2020 and cohort studies. Results: In total, 1166 articles were identified and 55 English-written articles were included based on the risk of bias. Of all COVID-19-hospitalized patients presenting with AKI (n = 18029) classified as Kidney Disease Improving Global Outcomes stage 1 to 3, approximately 18% required mechanical ventilation and 39.2 % died. Around 11.3% of the patients required kidney replacement therapy (KRT) and of these, 1093 died and 321 required continuous KRT. Death is more frequent in individuals with AKI [OR 6.03, 95%CI: 5.73-6.74; p<0.01]. Finally, mechanical ventilation is an aggravating factor in the clinical conditions studied [OR 11.01, 95%CI: 10.29-11.77; p<0.01]. Conclusion: Current literature indicates AKI as an important complication in COVID-19. In this context, we observed that comorbidities, such as chronic kidney disease and heart failure, were more related to the development of AKI. In addition, mechanical ventilation was seen as an aggravating factor in this scenario.

Resumo Antecedentes: Lesão renal aguda (LRA) é uma complicação frequente da doença do coronavírus-19 (COVID-19). Desta forma, decidimos realizar uma revisão sistemática e uma metanálise com dados da literatura para relacionar o desenvolvimento de LRA associada à COVID-19 com comorbidades, medicamentos e o impacto da ventilação mecânica. Métodos: Realizamos uma revisão sistemática usando a escala de Newcastle-Ottawa e uma metanálise utilizando o programa R. Estudos relevantes foram pesquisados nos bancos de dados eletrônicos PubMed, Medline e SciELO. Foram utilizados filtros de pesquisa para incluir relatos após 2020 e estudos de coorte. Resultados: No total, foram identificados 1166 artigos, e foram incluídos 55 artigos escritos em língua inglesa com base no risco de viés. De todos os pacientes hospitalizados por COVID-19 apresentando LRA (n = 18029) classificados como Kidney Disease Improving Global Outcomes estágios 1 a 3, aproximadamente 18% necessitaram de ventilação mecânica e 39,2% foram a óbito. Cerca de 11,3% dos pacientes necessitaram de terapia renal substitutiva (TRS) e destes, 1093 foram a óbito e 321 necessitaram de TRS contínua. O óbito é mais frequente em indivíduos com LRA [OR 6,03; IC95%: 5,73-6,74; p<0,01]. Por fim, a ventilação mecânica é um fator agravante nas condições clínicas estudadas [OR 11,01; IC95%: 10,29-11,77; p<0,01]. Conclusão: A literatura atual indica a LRA como uma complicação importante na COVID-19. Neste contexto, observamos que comorbidades, como doença renal crônica e insuficiência cardíaca, estiveram mais relacionadas ao desenvolvimento de LRA. Além disso, a ventilação mecânica foi vista como um fator agravante neste cenário.

https://doi.org/10.1590/2175-8239-jbn-2022-0013en

Water supply failure probability under influence of climate change - Balsillas river basin case study
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Mena Rentería, Darwin

; Espinosa, Eydy Michell

; Soler, Paula Carolina

; Cañón Ramos, Miguel

; Duarte, Freddy Santiago

; Palacios Gonzalez, Jordi Rafael

Revista Facultad de Ingeniería Universidad de Antioquia

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Jun 2022, Nº 103 Páginas 9 - 19

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN Este proyecto evalúa el riesgo de falla del suministro de agua para el sector agrícola en condiciones de cambio climático mediante la implementación de modelos hidrológicos que apoyan la toma de decisiones para satisfacer las demandas de consumo en tiempos de escasez. Este proyecto se desarrolló a través de una metodología que utiliza herramientas de modelado hidrológico como el software HydroBID y los modelos de gestión de recursos hídricos SIMGES y SIMRISK de AQUATOOL DSS. Las series de caudales para un escenario futuro se obtuvieron para diferentes escenarios de cambio climático a partir de un Modelo Climático Global (GCM) y el Experimento Regional Coordinado de Reducción del Clima (CORDEX) reduciendo la escala de los resultados de la escala global a la escala de cuenca utilizando un método estadístico basado en la teoría del caos. Estas proyecciones muestran que, en condiciones de cambio climático, el sector agrícola de la cuenca del Balsillas no sufrirá impactos significativos ya que podrá satisfacer la mayoría de los puntos de demanda.

ABSTRACT This project assesses the risk of water supply failure for the agricultural sector under climate change conditions by implementing hydrological models that support decision-making for satisfying consumptive demands in times of scarcity. This project was developed using hydrological modeling tools such as the HydroBID software and the SIMGES and SIMRISK water resource management models of AQUATOOL DSS. The flow series for a future scenario were obtained for different climate change scenarios from a Global Climate Model (GCM) and the Coordinated Regional Experiment on Climate Reduction (CORDEX) by downscaling the results from the global scale to basin-scale using a statistical method based on chaos theory. These projections show that under conditions of climate change, the agricultural sector of the Balsillas basin will not suffer significant impacts since they will be able to satisfy most demand points.

https://doi.org/10.17533/udea.redin.20201008 40 downloads

Impacto sobre la incidencia de la tuberculosis en Cuba, 1994-2015
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García Cortina, José Ramón

; Ferrán Torres, Rita María

; Gonzalez Dias, Alexander

; Martínez Morales, Miguel Ángel

; González Ochoa, Edilberto

Revista Cubana de Salud Pública

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Jun 2022, Volume 48 Nº 2 elocation e2388

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Incidence is critical to assess the burden of tuberculosis. Objective: Assess the impact of the "National Program of Tuberculosis Control " on the incidence of tuberculosis in Cuba in the period 1994-2015. Methods: Study of time series of tuberculosis incidence in the period 1994-2015. The exponential trend and variations in the trends of new cases reported in Cuba and its provinces were estimated; also the annual totals and averages for the periods 1994-1999, 1999-2015 and 1994-2015. The absolute and relative differences between the Cuban provinces from 1994-2015 were calculated. Results: The overall trend of the rate was downward. The period from 1994-1999 had a reduction of -0.33x100 000 (-505 cases) and between 1999 and 2015 it was -0.42 (-448 cases). The average annual reduction between 1994-1999 was -0.07 and from 1999-2015 it was -0.03. In 1994, 1999 and 2015, 1616 cases (14.7), 1111 (10.0) and 651 (5.8) were reported, respectively. In 1994 the highest rate corresponded to the province of Cienfuegos (23.1) with a percentage population attributable risk of 65.8%. In 1999 and 2015, the highest rates occurred in Ciego de Ávila (18.3) and (9.5), respectively (percentage population attributable risk of 60.7% in 1999 and 75.8% in 2015). In 1994 and 1999 all provinces had rates > 5.0. In 2015, eight provinces showed rates < 5.0. In 1999 the province with the greatest variation in its annual rate was Cienfuegos (-0.65) and in 2015 Camagüey (-0.73). Conclusions: The "National Program of Tuberculosis Control " in Cuba obtained until 2015 a discreet sustained decrease in the incidence of the disease in the country; but it is not enough to achieve its elimination, so new differentiated and prioritized interventions are required.

RESUMEN Introducción: La incidencia es fundamental para evaluar la carga de tuberculosis. Objetivo: Valorar el impacto del “Programa Nacional de Control de la Tuberculosis” en la incidencia de la tuberculosis en Cuba en el periodo 1994-2015. Métodos: Estudio de series temporales de la incidencia de tuberculosis en el periodo 1994-2015. Se estimó la tendencia exponencial y las variaciones de las tendencias de casos nuevos notificados en Cuba y sus provincias; los totales y medias anuales de los periodos 1994-1999, 1999-2015 y 1994-2015. Se calcularon las diferencias absolutas y relativas entre las provincias cubanas desde 1994-2015. Resultados: La tendencia general de la tasa fue descendente. El periodo de 1994-1999 visualizó una reducción de -0,33x100 000(-505 casos) y entre 1999 y 2015 fue de -0,42(-448 casos). La reducción media anual entre 1994-1999 fue de -0,07 y de 1999-2015 fue de -0,03. En 1994, 1999 y 2015 se notificaron 1616 casos (14,7), 1111(10,0) y 651(5,8), respectivamente. En 1994 la mayor tasa correspondió a la provincia de Cienfuegos (23,1) con riesgo atribuible poblacional porcentual del 65,8 %. En 1999 y 2015 las mayores tasas se presentaron en Ciego de Ávila (18,3) y (9,5), respectivamente (riesgo atribuible poblacional porcentual del 60,7 % en 1999 y del 75,8 % en 2015). En 1994 y 1999 todas las provincias tuvieron tasas > 5,0. En 2015, ocho provincias mostraron tasas < 5,0. En 1999 la provincia con mayor variación de su tasa anual fue Cienfuegos (-0,65) y en 2015 Camagüey (-0,73). Conclusiones: El “Programa Nacional de Control de la Tuberculosis” en Cuba obtuvo hasta el 2015 una discreta disminución sostenida de la incidencia de la enfermedad en el país; pero no es suficiente para lograr su eliminación, por lo que se requieren nuevas intervenciones diferenciadas y priorizadas.

Perforación colónica y sepsis fulminante asociada a Clostridium septicum como presentación de un cáncer de colon
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Nicolas, Miguel

; Huaier-Arriazu, Emilio

; Perez, Karina

; Gonzalez-Salazar, Esteban

Revista chilena de infectología

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Jun 2022, Volume 39 Nº 3 Páginas 354 - 356

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract The association between some bacterial infections and colon cancer is well documented. The most described is Streptococcus bovis infection. Another bacteria related to intestinal neoplasms is Clostridium septicum. We present the case of a 62-year-old man who consulted for abdominal pain associated with diarrhea and fever. A computed tomography scan of the abdomen and pelvis was performed, which revealed thickening of the cecum walls with an apparent break in continuity at its free edge. An exploratory laparotomy was performed which confirmed the presence of peritonitis and cecal perforation. A right hemicolectomy and terminal ileostomy were performed. The histopathological study revealed the presence of signet ring cell type adenocarcinoma associated with ischemia. The blood cultures results demonstrated the presence of C. septicum. The patient died due to fulminant sepsis.

Resumen La asociación entre algunas infecciones bacterianas y cáncer de colon está bien documentada. La más descrita es la infección por Streptococcus bovis. Otra bacteria relacionada a neoplasias intestinales es Clostridium septicum. Presentamos el caso clínico de un varón de 62 años que consultó por dolor abdominal, diarrea y fiebre. Se realizó una tomografía computada de abdomen y pelvis que evidenció un engrosamiento de las paredes del ciego con una aparente solución de continuidad en su borde libre. En una laparotomía exploradora se confirmó la presencia de peritonitis y perforación cecal, siendo sometido a una hemicolectomía derecha e ileostomía terminal. El estudio histopatológico reveló la presencia de un adenocarcinoma de tipo células en anillo de sello asociado a isquemia. Los hemocultivos fueron positivos a C. septicum. El paciente falleció por una sepsis fulminante.

https://doi.org/10.4067/s0716-10182022000200354 155 downloads

Low molecular weight heparin is useful in adult COVID-19 inpatients. Experience during the first Spanish wave: observational study
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Gonzalez-Porras, Jose Ramon

; Belhassen-Garcia, Moncef

; Lopez-Bernus, Amparo

; Vaquero-Roncero, Luis Mario

; Rodriguez, Beatriz

; Carbonell, Cristina

; Azibeiro, Raul

; Hernandez-Sanchez, Alberto

; Martin-Gonzalez, Jose Ignacio

; Manrique, Juan Miguel

; Alonso-Claudio, Gloria

; Alvarez-Navia, Felipe

; Madruga-Martin, Jose Ignacio

; Macias-Casanova, Ronald Paul

; García-Criado, Jorge

; Lozano, Francisco

; Moyano, Jose Carlos

; Sanchez-Hernandez, Miguel Vicente

; Sagredo-Meneses, Víctor

; Borras, Rafael

; Bastida, Jose María

; Hernández-Pérez, Guillermo

; Chamorro, Antonio Javier

; Marcos, Miguel

; Martin-Oterino, Jose Angel

Sao Paulo Medical Journal

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Fev 2022, Volume 140 Nº 1 Páginas 123 - 133

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: The intensity of the thromboprophylaxis needed as a potential factor for preventing inpatient mortality due to coronavirus disease-19 (COVID-19) remains unclear. OBJECTIVE: To explore the association between anticoagulation intensity and COVID-19 survival. DESIGN AND SETTING: Retrospective observational study in a tertiary-level hospital in Spain. METHODS: Low-molecular-weight heparin (LMWH) status was ascertained based on prescription at admission. To control for immortal time bias, anticoagulant use was analyzed as a time-dependent variable. RESULTS: 690 patients were included (median age, 72 years). LMWH was administered to 615 patients, starting from hospital admission (89.1%). 410 (66.7%) received prophylactic-dose LMWH; 120 (19.5%), therapeutic-dose LMWH; and another 85 (13.8%) who presented respiratory failure, high D-dimer levels (> 3 mg/l) and non-worsening of inflammation markers received prophylaxis of intermediate-dose LMWH. The overall inpatient-mortality rate was 38.5%. The anticoagulant nonuser group presented higher mortality risk than each of the following groups: any LMWH users (HR 2.1; 95% CI: 1.40-3.15); the prophylactic-dose heparin group (HR 2.39; 95% CI, 1.57-3.64); and the users of heparin dose according to biomarkers (HR 6.52; 95% CI, 2.95-14.41). 3.4% of the patients experienced major hemorrhage. 2.8% of the patients developed an episode of thromboembolism. CONCLUSIONS: This observational study showed that LMWH administered at the time of admission was associated with lower mortality among unselected adult COVID-19 inpatients. The magnitude of the benefit may have been greatest for the intermediate-dose subgroup. Randomized controlled trials to assess the benefit of heparin within different therapeutic regimes for COVID-19 patients are required.

https://doi.org/10.1590/1516-3180.2021.0098.r1.08062021

10.

Autonomic dysfunction is common in liver cirrhosis and is associated with cardiac dysfunction and mortality: prospective observational study
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Pimentel, Carolina Frade Magalhães Girardin

; Salvadori, Ricardo

; Feldner, Ana Cristina de Castro Amaral

; Aguiar, Miguel Osman de

; Gonzalez, Adriano Miziara

; Branco, Gabriel Ribas

; Superbia, Marcel

; Lai, Michelle

; Mota, Daniel de Oliveira

; Ferraz, Maria Lucia Cardoso Gomes

; Mathias, Wilson

; Kondo, Mario

Sao Paulo Medical Journal

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Fev 2022, Volume 140 Nº 1 Páginas 71 - 80

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Although autonomic dysfunction has been shown to be associated with liver cirrhosis, the prevalence and prognostic implications are unclear. Abnormal heart rate variability (HRV), a measure of autonomic function, has not been well investigated in cirrhosis. OBJECTIVE: To evaluate the prevalence of high-risk HRV parameters in a cohort of cirrhotic patients and their association with cardiac dysfunction and mortality. DESIGN AND SETTING: Prospective observational study conducted in the Federal University of São Paulo. METHOD: A cohort of 120 patients, comprising 17 healthy controls and 103 cirrhotic outpatients, was evaluated and followed for 10 months. HRV analysis was based on 24-hour Holter monitoring and defined using time-domain and frequency-domain parameters. RESULTS: The HRV parameters were statistically lower in cirrhotic patients than in healthy subjects. High-risk HRV parameters were prevalent, such that 64% had at least one high-risk parameter. Time-domain parameters correlated with Child scores (P < 0.0001). In regression models, HRV parameters were independent predictors of diastolic dysfunction and mortality. During 10 months of follow-up, there were 11 deaths, all of patients with at least one high-risk HRV parameter. Kaplan-Meier analysis estimated low survival rates among patients with standard deviation of normal-to-normal RR intervals (SDNN) < 100. CONCLUSION: Reduced HRV is prevalent in liver cirrhosis and is related to cardiac dysfunction, severity of liver disease and mortality. Abnormal high-risk HRV parameters are prevalent among cirrhotic patients and are also predictors of mortality. Our findings highlight the need for a more careful cardiac evaluation of cirrhotic patients.

https://doi.org/10.1590/1516-3180.2021.0111.r1.18052021

11.

Parkinson’s disease in the state of Michoacan, evolution, and treatment
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García-Villa, Marcela

; Leal-Cantú, Raúl

; Madrigal-Salas, Rosa G.

; Rodríguez-Leyva, Ildefonso

; Quintana-Díaz, Mariana A.

; Gonzalez-García, Conne L.

Revista mexicana de neurociencia

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Fev 2022, Volume 23 Nº 1 Páginas 14 - 21

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objective: This work is the first registry focused on knowing patients’ characteristics with Parkinson’s disease (PD), evolution and treatment used in the state of Michoacán. Methods: 68 patients with PD from the neurology consultation of the General Hospital “Dr. Miguel Silva” from October 1, 2019, to December 31, 2019, who fulfilled the UKPDSBB criteria, were studied. Sociodemographic data, disease duration, and severity according to the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and Hoehn and Yahr Scale were collected. Results: A total of 68 patients were included in the study. Seven of them were eliminated for not meeting the inclusion criteria. Of the 61 evaluated, 31 (50.8%) were women, the mean age was 68 years (± 9.8) and the age of diagnosis was 61 years (± 12.6). The predominant comorbidities were diabetes mellitus (16.4%), systemic arterial hypertension (44.3%), and depression (70.5%). The dominant phenotype was rigid-akinetic, with absence or slight tremor in 50.8%. About 36.1% had between 5 and 10 years of suffering from the disease. 36.1% had exposure to pesticides; 31.1% had a history of head trauma. There were 24.6% smoking and 31.1% alcoholism. The drugs most used for motor manifestations were levodopa/carbidopa in 83.6% and pramipexole in 31.1 %. In part I of the MDS-UPDRS scale, the mean score was 9.8 ± 6.0; part II 14.37 ± 9.6; part III 21.22 ± 12.4 and part IV 3.2 ± 3.69. HY, I occupied 37.7%; II 26.2%; III 23%; IV 9.8% and V 3.3%. Conclusions: In this population, the disease occurred without distinction of gender. The only treatment was pharmacological. Rehabilitation, the support of the psychiatrist and nutritionists, is essential for comprehensive management.

Resumen Objetivo: Este trabajo es el primer registro enfocado en conocer las características, evolución y tratamiento de los pacientes con enfermedad de Parkinson (EP) utilizados en el estado de Michoacán. Material y métodos: Se estudiaron 68 pacientes con EP de la consulta de neurología del Hospital General “Dr. Miguel Silva” del 1 de octubre de 2019 al 31 de diciembre de 2019, que cumplieran con los criterios de la UKPDSBB. Se recogieron datos sociodemográficos, duración y gravedad de la enfermedad según la Escala Unificada de Calificación de la Enfermedad de Parkinson (MDS-UPDRS) y la Escala de Hoehn y Yahr. Resultados: Se incluyó a un total de 68 pacientes. Siete de ellos fueron eliminados por no cumplir con los criterios de inclusión. De los 61 evaluados, 31 (50.8%) eran mujeres, la edad media fue de 68 años ± 9.8 años y la edad de diagnóstico fue de 61 años ± 12.6. Las comorbilidades predominantes fueron diabetes mellitus (16.4%), hipertensión arterial sistémica (44.3%) y depresión (70.5%). El fenotipo dominante fue rígido-acinético, con ausencia o leve temblor en el 50.8%. El 36.1% tenía entre 5 y 10 años de padecer la enfermedad. 36.1% tuvo exposición a plaguicidas y 31.1% tenía antecedentes de traumatismo craneoencefálico. Los fármacos más utilizados para las manifestaciones motoras fueron levodopa/carbidopa en el 83.6% y pramipexol en 31.1%. En la parte I de la escala MDS-UPDRS, la puntuación media fue de 9.8 ± 6,0; parte II, 14.37 ± 9.6; parte III 21.22 ± 12.4 y en la parte IV 3.2 ± 3.69. HY, I ocupó 37.5%; II 26.2%; III 23%; IV 9.8% y V 3.3%. Conclusiones: En esta población la enfermedad se presentó sin distinción de género. El único tratamiento fue farmacológico. La rehabilitación, el apoyo del psiquiatra y nutriología se hacen indispensables para el manejo integral.

https://doi.org/10.24875/rmn.21000018 49 downloads

12.

Adverse effects associated with peribulbar injection of triamcinolone for the treatment of thyroid eye disease: a retrospective case series
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Barlatay, Joaquin Miguel Gonzalez

; Boza, Carla Pagano

; Basso, Tomaz Ortiz

; Benavente, Mercedes

; Hernández-Gauna, Guillermo Vicente

; Premoli, Eduardo Jorge

Arquivos Brasileiros de Oftalmologia

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2022, Nº ahead

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/0004-2749.20230063

13.

Heritable genomic diversity in breast cancer driver genes and associations with risk in a Chilean population
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Morales-Pison, Sebastian

; Gonzalez-Hormazabal, Patricio

; Tapia, Julio C.

; Salas-Burgos, Alexis

; Ampuero, Sandra

; Gómez, Fernando

; Waugh, Enrique

; Reyes, José Miguel

; Jara, Lilian

Biological Research

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2022, Volume 55 elocation 20

Resumo: En | Texto: En | PDF: En

Abstract Background: Driver mutations are the genetic components responsible for tumor initiation and progression. These variants, which may be inherited, influence cancer risk and therefore underlie many familial cancers. The present study examines the potential association between SNPs in driver genes SF3B1 (rs4685), TBX3 (rs12366395, rs8853, and rs1061651) and MAP3K1 (rs72758040) and BC in BRCA1/2-negative Chilean families. Methods: The SNPs were genotyped in 486 BC cases and 1258 controls by TaqMan Assay. Results: Our data do not support an association between rs4685:C > T, rs8853:T > C, or rs1061651:T > C and BC risk. However, the rs12366395-G allele (A/G + G/G) was associated with risk in families with a strong history of BC (OR = 1.2 [95% CI 1.0–1.6] p = 0.02 and OR = 1.5 [95% CI 1.0–2.2] p = 0.02, respectively). Moreover, rs72758040-C was associated with increased risk in cases with a moderate-to-strong family history of BC (OR = 1.3 [95% CI 1.0–1.7] p = 0.02 and OR = 1.3 [95% CI 1.0–1.8] p = 0.03 respectively). Finally, risk was significantly higher in homozygous C/C cases from families with a moderate-to-strong BC history (OR = 1.8 [95% CI 1.0–3.1] p = 0.03 and OR = 1.9 [95% CI 1.1–3.4] p = 0.01, respectively). We also evaluated the combined impact of rs12366395-G and rs72758040-C. Familial BC risk increased in a dose-dependent manner with risk allele count, reflecting an additive effect (p-trend = 0.0002). Conclusions: Our study suggests that germline variants in driver genes TBX3 (rs12366395) and MAP3K1 (rs72758040) may influence BC risk in BRCA1/2-negative Chilean families. Moreover, the presence of rs12366395-G and rs72758040-C could increase BC risk in a Chilean population.

https://doi.org/10.1186/s40659-022-00384-4 42 downloads

14.

Solitary fibrofolliculoma: a retrospective case series review over 18 years
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Díez-Montero, Cecilia

; Alonso, Miguel Diego

; Marquez, Pilar I. Gonzalez

; Schellini, Silvana Artioli

; Galindo-Ferreiro, Alicia

Arquivos Brasileiros de Oftalmologia

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Dez 2020, Volume 83 Nº 6 Páginas 485 - 489

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: o objetivo deste estudo foi relatar uma série de casos de fibrofoliculoma solitário, uma lesão raramente observada nas pálpebras. Demografia, bem como aspectos clínicos e histológicos da lesão foram avaliados. Métodos: Trata-se de uma série de casos retrospectivos, com um período de 18 anos. Todos os pacientes incluídos foram diagnosticados com fibrofoliculoma solitário confirmado por exame histológico. Foram coletados dados referentes à demografia, sinais e sintomas dos pacientes, evolução da doença, localização da lesão, diagnóstico clínico e histológico e desfecho. Resultados: Onze casos de fibrofoliculoma solitário foram diagnosticados no período do estudo. A média de idade dos pacientes de 51 ± 16,3 anos (variação: 27-78 anos). A maioria dos pacientes era do sexo feminino (7/11, 64%). Cinco dos pacientes (45%) eram assintomáticos; quatro (36%) relataram sangramento, um (9%) referiu coceira e um (9%) fricção da lesão. A lesão ocorreu em luma ampla variedade de locais; um deles sendo nas pálpebras. O diagnóstico de todas as lesões foi histológico com base nos achados característicos de um folículo piloso ocasionalmente dilatado e contendo material de queratina, cercado por um manto espesso de tecido fibroso moderadamente bem circunscrito. O epitélio infundibular folicular se estendeu até esse manto fibroso, formando cordões ou cordões epiteliais. Não houve recaídas após exérese. Conclusão: Fibrofoliculoma solitário é uma lesão rara, mais ainda quando afeta as pálpebras. Relatamos 11 casos, e o terceiro relatado até o momento na literatura que afeta as pálpebras. O diagnóstico pode ser facilmente esquecido devido a sintomas inespecíficos e aparência clínica. Portanto, é necessário realizar biópsia excisional e exame histológico para o reconhecimento dessa lesão.

ABSTRACT Purpose: The purpose of this study was to report a series of cases of solitary fibrofolliculoma, a lesion seldom observed in the lids. Demographics, as well as clinical and histological aspects of the lesion were evaluated. Methods: This was a retrospective case series spanning a period of 18 years. All the included patients were diagnosed with solitary fibrofolliculoma confirmed by histological examination. Data regarding patient demographics, signs, and symptoms, course of the disease, location of the lesion, clinical and histological diagnosis, and outcome were collected. Results: Eleven cases of solitary fibrofolliculoma were diagnosed in the study period. The median age of patients was 51 ± 16.3 years (range: 27-78 years). Most patients were females (7/11; 64%). Five of the patients (45%) were asymptomatic; four (36%) reported bleeding, one (9%) had referred itching, and one (9%) rubbing of the lesion. The lesion occurred in a wide range of locations; one of them was located in the lids. The diagnosis for all lesions was histological based on characteristic findings of a hair follicle occasionally dilated and containing keratin material surrounded by a moderately well-circumscribed thick mantle of fibrous tissue. The infundibular follicular epithelium extended out into this fibrous mantle forming epithelial strands or cords. There were no relapses after exeresis. Conclusion: Solitary fibrofolliculoma is a rare lesion, seldom affecting the eyelids. We reported 11 cases, and the third case reported thus far in the literature affecting the lids. Diagnosis may be easily missed due to the nonspecific symptoms and clinical appearance. Therefore, it is necessary to perform excisional biopsy and histological examination for the recognition of this lesion.

https://doi.org/10.5935/0004-2749.20200092 332 downloads

15.

Automatic Detection of Social Isolation Based on Human Behavior Analysis
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Martinez Rebollar, Alicia

; Gonzalez Mendoza, Miguel

; Estrada Esquivel, Hugo

; Campos Francisco, Wilfrido

; Campos Ortiz, Virginia

Computación y Sistemas

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Dez 2020, Volume 24 Nº 4 Páginas 1527 - 1538

Resumo: En | Texto: En | PDF: En

Abstract: Social isolation is a problem that is accentuated in the stage of old age. This condition puts the physical and mental integrity of older adults at risk. This paper presents a predictive model for the automatic detection of social isolation in older adults. The predictive model was implemented in a mobile application that monitors communication and mobility activities performed by an older adult. The mobile application was also generated for a caregiver who is responsible for receiving notifications about the specific level of social isolation of the older adult. The predictive model was evaluated using an experimental group of older adults.

https://doi.org/10.13053/cys-24-4-3444 117 downloads

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